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Haase, David; Rieger, J K; Witten, A; Stoll, M; Bornberg-Bauer, E; Kalbe, M; Reusch, Thorsten B H: The effect of repeated exposure to parasite genotypes of the eyefluke Diplostomum pseudospathaceum on infection rate and immunization in three-spined sticklebacks [dataset publication series]. PANGAEA, https://doi.pangaea.de/10.1594/PANGAEA.843814 (dataset in review), Supplement to: Haase, D et al. (2016): Immunity comes first: The effect of parasite genotypes on adaptive immunity and immunization in three-spined sticklebacks. 54(1), 137-144, https://doi.org/10.1016/j.dci.2015.09.008

Abstract:
Adaptive immunity in vertebrates can confer increased resistance against invading pathogens upon re-infection. But how specific parasite genotypes affect the transition from innate to adaptive immunity is poorly understood. Here, we investigated the effects of homologous and heterologous exposures of genetically distinct parasite lineages of the eye fluke Diplostomum pseudospathaceum on gene expression patterns of adaptive immunity in sticklebacks (Gasterosteus aculeatus). We showed that observable differences were largely attributable to final exposures and that there is no transcription pattern characteristic for a general response to repeated infections with D. pseudospathaceum. Final exposure did not unify expression patterns of heterologous pre-exposed fish. Interestingly, heterologous final exposures showed similarities between different treatment groups subjected to homologous pre-exposure. The observed pattern was supported by parasite infection rates and suggests that host immunization was optimized towards an adaptive immune response that favored effectiveness against parasite diversity over specificity.
License:
Creative Commons Attribution 3.0 Unported (CC-BY-3.0) (License comes into effect after moratorium ends)
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2 datasets

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Datasets listed in this publication series

  1. Haase, D (in review): The effect of repeated exposure to parasite genotypes of the eyefluke Diplostomum pseudospathaceum on infection rate and immunization in three-spined sticklebacks: Mass infection. https://doi.pangaea.de/10.1594/PANGAEA.843810
  2. Haase, D (in review): The effect of repeated exposure to parasite genotypes of the eyefluke Diplostomum pseudospathaceum on infection rate and immunization in three-spined sticklebacks: RNA. https://doi.pangaea.de/10.1594/PANGAEA.843813